076 THE PERIPHERAL EFFECTS OF GROUP II AND III METABOTROPIC GLUTAMATE RECEPTORS ON KNEE JOINT ARTHRITIC PAIN IN RATS
نویسندگان
چکیده
منابع مشابه
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15 صفحه اولGroup II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors.
There is pharmacological evidence that group II and III metabotropic glutamate receptors (mGluRs) function as activity-dependent autoreceptors, inhibiting transmission in supraspinal sites. These receptors are expressed by peripheral nociceptors. We investigated whether mGluRs function as activity-dependent autoreceptors inhibiting pain transmission to the rat CNS, particularly transient recept...
متن کاملGroup III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain.
Glutamate plays a key role in modulation of nociceptive processing. This excitatory amino acid exerts its action through two distinct types of receptors, ionotropic and metabotropic glutamate receptors (mGluRs). Eight mGluRs have been identified and divided in three groups based on their sequence similarity, pharmacology and G-protein coupling. While the role of group I and II mGluRs is now wel...
متن کاملGroup III Metabotropic Glutamate Receptors (mGlu4, mGlu6, mGlu7, and mGlu8)
G protein-coupled group III metabotropic glutamate receptors (mGluRs) include four subtypes that are negatively coupled to adenylyl cyclase (mGluRs 4, 7, and 8) or positively to a cGMP phosphodiesterase (mGluR6). Typically, they exert inhibitory influences on neuronal activity. This chapter reviews the characteristics of group III mGluRs and their normal functions and role in nervous system dis...
متن کاملStructures of the extracellular regions of the group II/III metabotropic glutamate receptors.
Metabotropic glutamate receptors play major roles in the activation of excitatory synapses in the central nerve system. We determined the crystal structure of the entire extracellular region of the group II receptor and that of the ligand-binding region of the group III receptor. A comparison among groups I, II, and III provides the structural basis that could account for the discrimination of ...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2009
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(09)60099-6